positional cloning of the mouse obese gene and its human homologue pdf

Positional Cloning Of The Mouse Obese Gene And Its Human Homologue Pdf

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This special issue of Journal of Endocrinology celebrates the 20th anniversary of the discovery of leptin, a hormone produced by adipose tissue, which provides critical signals to the organism regarding the status of its energy stores. The discovery of leptin not only revolutionised our understanding of endocrine physiology but has also resulted in a registered medicinal product which is already improving the health of patients with serious metabolic diseases. I devoured the accompanying article with a growing sense of nuchal pilo-erection! Given the limited technical resources available at the time, the identification of that circulating factor through positional genetic methods in the mouse was a tour de force requiring prodigious vision, courage, dedication and skill. I am delighted therefore that, in putting together this volume celebrating the discovery of leptin 20 years ago, Jeff Friedman has contributed a personal piece reflecting on the process of leptin's discovery and adumbrating the questions that remain Friedman

ob/ob mouse

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Reprints and Permissions.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese ob gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans.

Positional cloning of the mouse obese gene and its human homologue

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Zhang and R. Proenca and M. Maffei and M. Barone and L.


Positional cloning of the mouse obese gene and its human homolog. January ; Nature () DOI: /a0.


ob/ob mouse

Single nucleotide polymorphisms SNPs and the search for obesity-related genes. Debora M. Worldwide, its economic burden is thought to be around billion of dollars in direct health care costs and also the cost of lost productivity in affected individuals.

Positional cloning of the mouse obese gene and its human homologue Published on Dec 1, in Nature Yiying Zhang 17 Estimated H-index: Find in Lib. Add to Collection. The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean.

Leptin pp Cite as. Early theories describing appetite regulation and energy expenditure suggested the lipostatic theory, which hypothesized that some peripheral signal, probably from adipose tissue, would feedback to central satiety centers to modulate food intake and body weight. However, the experimental techniques needed to validate this hypothesis were lacking at that time.

20 YEARS OF LEPTIN: What we know and what the future holds

Positional cloning of the mouse obese gene and its human homologue

Exercising the obese brain: Resetting the defended body weight. Endocrinology ; J Appl Physiol ; WHO Expert Consultation. Lancet ;

Leon J. Spicer, Cristina C. Leptin, a recently-discovered hormonal product of the obese gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety and improves reproductive performance if injected into mice lacking circulating leptin. Therefore, we tested the hypothesis that leptin signals metabolic information to the reproductive system by directly affecting granulosa cell function. Leptin did not compete for specific I-insulin binding to granulosa cells. Furthermore, specific binding of I-leptin was demonstrable in granulosa cells. In conclusion, leptin, at physiological levels, can directly attenuate insulin-induced steroidogenesis of granulosa cells without affecting proliferation of this ovarian cell type.

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese ob gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Reprints and Permissions. Zhang, Y. Positional cloning of the mouse obese gene and its human homologue.

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Leptin is an important hormone possessing diverse physiological roles in mammals and teleosts. However, it has been characterized only in a few amphibian species, and its evolutions are still under debate. Here, the full length of the leptin Adlep cDNA of Chinese giant salamander Andrias davidianus , an early diverging amphibian species, is characterized and according to the results of the primary sequence analysis, tertiary structure reconstruction and phylogenetic analysis is confirmed to be an ortholog of mammalian leptin. An intron was identified between the coding exons of A.

Час сорок пять ночи. Он в недоумении посмотрел на двухцветного. - Ты сказал - в два ночи. Панк кивнул и расхохотался.

Затем поднял коробку, поставил ее на стол и вытряхнул содержимое. Аккуратно, предмет за предметом, перетряхнул одежду. Затем взял ботинки и постучал каблуками по столу, точно вытряхивая камешек. Просмотрев все еще раз, он отступил на шаг и нахмурился. - Какие-то проблемы? - спросил лейтенант.

Даже в полуметре от шефа она не видела очертаний его фигуры. Всякий раз, ступая на очередную ступеньку, она носком туфли первым делом старалась нащупать ее край.

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