advanced glycation end products and diabetes pdf

Advanced Glycation End Products And Diabetes Pdf

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Metrics details. Traditional risk factors are insufficient to explain all cases of coronary artery disease CAD in patients with diabetes mellitus DM. Advanced glycation end-products AGEs and their receptors may play important roles in the development and progression of CAD.

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Advanced glycation end-product

The occurrence and development of cardiovascular complications are predominantly responsible for the increased morbidity and mortality observed in patients with diabetes. Oxidative stress under hyperglycemia is currently considered the initial link to diabetic cardiovascular complications and a key node for the prevention and treatment of diabetes-related fatal cardiovascular events. Numerous studies have indicated that the common upstream pathway in the context of oxidative stress in the cardiovascular system under diabetic conditions is the interaction of advanced glycation end products AGEs with their receptors RAGEs. Therefore, a further understanding of the relationship between oxidative stress and AGEs is of great significance for the prevention and treatment of cardiovascular complications in patients with diabetes. In this review, we will briefly summarize the recent research advances in diabetes with an emphasis on oxidative stress and its association with AGEs in diabetic cardiovascular complications.

The Role of Advanced Glycation End Products in Diabetic Vascular Complications

In cases of chronic hyperglycemia, advanced glycation end-products AGEs are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications. The Sulwon Award for Scientific Achievement is the Korean Diabetes Association's highest scientific award and honors an individual who has excellently contributed to the progress in the field of diabetes and metabolism.

Advanced glycation end products ( AGEs ) in diabetes

It is the best journal to keep up to date with endocrine pathophysiology both in the clinical and in the research field. It publishes the best original articles of large research institutions, as well as prestigious reviews. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. CiteScore measures average citations received per document published. Read more.

Advanced glycation end products AGEs are proteins or lipids that become glycated as a result of exposure to sugars. Animal-derived foods that are high in fat and protein are generally AGE-rich and are prone to further AGE formation during cooking.

Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both?

The formation of advanced glycation end products AGEs is an important biochemical abnormality that accompanies diabetes mellitus and, likely, inflammation in general. Here we summarize and discuss recent studies indicating that the effects of AGEs on vessel wall homeostasis may account for the rapidly progressive atherosclerosis associated with diabetes mellitus. Driven by hyperglycemia and oxidant stress, AGEs form to a greatly accelerated degree in diabetes. Interaction of AGEs with endothelial cells as well as with other cells accumulating within the atherosclerotic plaque, such as mononuclear phagocytes and smooth muscle cells SMCs , provides a mechanism to augment vascular dysfunction.

Despite new and effective drug therapies, insulin resistance IR , type 2 diabetes mellitus T2D and its complications remain major medical challenges. It is accepted that IR, often associated with over-nutrition and obesity, results from chronically elevated oxidant stress OS and chronic inflammation. Less acknowledged is that a major cause for this inflammation is excessive consumption of advanced glycation end products AGEs with the standard western diet. We propose that under chronic exogenous oxidant AGE pressure the depletion of innate defense mechanisms is an important factor, which raises susceptibility to inflammation, IR, T2D and its complications. Finally we review evidence on dietary AGE restriction as a non-pharmacologic intervention, which effectively lowers AGEs, restores innate defenses and improves IR, thus, offering new perspectives on diabetes etiology and therapy. As the incidence of type 2 diabetes T2D continues to increase [ 1 ] and its multifactorial etiology is still debated, new evidence points to lifestyle factors as critical predisposing factors [ 2 , 3 ].

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PDF | Advanced glycation end products (AGEs) are formed in vivo by a non-​enzymatic reaction of proteins with carbohydrates and accumulate.


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1 Comments

  1. Yasmina T.

    The role of advanced glycation end-products AGEs in the development of vascular diabetic complications.

    12.04.2021 at 12:39 Reply

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